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Tirzepatide safety

Tirzepatide is a once-weekly GIP/GLP-1 medication for long-term weight management. Review who it's for, who shouldn't take it, and start your intake.

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Tirzepatide

tirzepatide · GIP/GLP-1 receptor agonist

Once-weekly subcutaneous injection

Tirzepatide activates two gut-hormone receptors (GIP and GLP-1). It reduces appetite, slows how quickly the stomach empties, and helps regulate blood sugar, so you feel full on less food.

Boxed Warning

Thyroid C-cell tumors: In rodent studies, tirzepatide caused thyroid tumors, including cancer. It is unknown whether it causes these in humans. Do not use if you or a family member has ever had medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

What it treats

Long-term weight management in adults with obesity (BMI ≥ 30), with a reduced-calorie diet and increased activity
Weight management in adults who are overweight (BMI ≥ 27) with a weight-related condition
Improving blood sugar control in adults with type 2 diabetes

Who shouldn't take it

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Prior serious allergic reaction to tirzepatide
Pregnancy or planning to become pregnant

Warnings & precautions

Pancreatitis — stop and seek care for severe, persistent abdominal pain
Gallbladder problems, including gallstones
Low blood sugar, especially with insulin or a sulfonylurea
Dehydration and acute kidney injury from nausea, vomiting, or diarrhea
May reduce the effectiveness of oral birth control — use a backup method or switch as advised

Common side effects

Nausea
Diarrhea
Vomiting
Constipation
Abdominal pain
Injection-site reactions

Call your clinician if you notice

A lump or swelling in the neck, hoarseness, or trouble swallowing (possible thyroid tumor)
Severe, persistent stomach pain (possible pancreatitis)
Symptoms of a serious allergic reaction

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. A licensed Forma clinician will review your health history and current medications to determine whether treatment is safe and appropriate for you. Never start, stop, or change a prescription without talking to a healthcare provider. If you think you may have a medical emergency, call 911.